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One characteristic feature is recurrence on the same sites a few hours after rechallenge with the same medication. FDE lesions usually resolve in 7-10 days, often leaving behind hyperpigmentation. It is characterized by solitary or multiple round or oval erythematous patches with dusky red centers, some of which may progress to bulla formation. Available from: įixed drug eruption (FDE) is a specific drug reaction that tends to recur in identical sites each time the responsible drug is taken. Int J Nutr Pharmacol Neurol Dis 2014 4, Suppl S1:39-43. Phenylbutazone-induced generalized bullous fixed drug eruption masquerading Stevens-Johnson syndrome/toxic epidermal necrolysis.
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How to cite this URL: Yadalla HK, Babu AR. Int J Nutr Pharmacol Neurol Dis 2014 4, Suppl S1:39-43 How to cite this article: Yadalla HK, Babu AR. Keywords: Generalized bullous fixed drug eruption, histopathology, phenylbutazone The present paper highlights the clinical importance of severe bullous FDE mimicking SJS and TEN, and the necessity of histopathologic confirmation in such cases. Histopathology of the lesion showed spongiosis, basal cell degeneration with numerous necrotic keratinocytes, and a superficial and deep perivascular infiltrate containing lymphocytes and eosinophils, along with melanin incontinence. Severe FDE was suspected due to lack of involvement of two mucosal sites and presence of mild constitutional symptoms. A 50-year-old female presented with sudden-onset widespread dusky red patches and denuded areas after intake of phenylbutazone for her arthritis. Herein, we report a case of generalized bullous fixed drug eruption (GBFDE) with extensive epidermal necrosis and detachment mimicking SJS/TEN overlap and TEN. Widespread bullous fixed drug eruption (FDE) is the most severe form of FDE and may be mistaken clinically for Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN).